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Keywords chiral drug;enantiomer;racemate resolution; 手性药物;对映体;消旋体拆分;
Keywords chiral drug;racemic switching;drug combination;chiral intermediates;chiral technology; 手性药物;外消旋转化;药物组合物;手性中间体;手性技术;
Keywords Chiral drugs;Asymmetric catalyse;Synthesis; 手性药物;不对称催化;合成;
Keywords chiral drugs;enantiomeric separation;HPLC;chiral stationary phases;stereoselective pharmacokinetics; 手性药物;对映体分离;高效液相色谱;手性固定相;立体选择性药物动力学;
Keywords Chiral ion-pair chromatography;Chiral ion-pair complex;Chiral drugs;Cinchona alkaloids;Camphorsulfonic acid; 手性离子对色谱法;手性离子对试剂;手性药物;金鸡纳生物碱;樟脑磺酸;
Now, the most important thing is to obtain one of the chiral drug enantiomers. 因此,获得单一对映体的药物成为一项重要的工作。
Chiral drugs are more important in new drugs. 手性药物在新药中越来越受重视。
Pharmacological interactions between the enantiomers may happen when a chiral drug was used as its racemate. 当手性药物以外消旋体供药用时,其对映体间就可能发生药效学和药代动力学的相互作用。
This article reviews the present applications of cyclodextrins in chiral drug resolution. 介绍了环糊精在手性药物拆分中的应用情况。
The research progress on applications of MIP in chiral drug separation and clinical drug analysis in the recent years was expounded. 综述了近年来分子印迹聚合物在手性药物分离和临床药物分析应用方面的研究进展。
The determination of absolute configuration for chiral compounds is one of the most important problem in the organic chemisty, especially for chiral drug synthesis. 手性化合物绝对构型的确定一直是有机化学特别是手性药物合成研究过程中经常遇到的问题之一。
The enantiomers of a chiral drug may have different properties in absorption, distribution, metabolism and/or elimination.This phenomenon is regarded as the stereoselectivity in pharmacokinetics. 药代动力学立体选择性是指手性药物对映体在吸收、分布、代谢和消除过程中有差异。
The enantiomers of a chiral drug may have different characters in absorption,distribution,metabolism and/or elimination.This phenomenon is regarded as the stereoselectivity in pharmacokinestics. 药动学立体选择性是指手性药物对映体在吸收、分布、代谢和/或排泄过程中具有差异。
Therefore the pervasiveness of chiral drug development and the rapid development of combinatorial synthesis demand simple, fast, reliable and sensitive methods for chiral analysis. 在分析化学领域，手性识别研究的方向是建立快速、准确、灵敏的手性分析方法。
Keywords chiral diols;venlafaxine;systhesis; 手性邻二醇;文拉法辛;合成;
Keywords Chiral compounds;Enantiomorph;Separation; 手性化合物;对映体;拆分;
The enantiomer of some chiral drugs has different pharmacology activity and different applying. 手性药物对映体具有不同的药理活性和不同的用途。
Keywords chiral;allylic amine;catalysis; 手性;烯丙基胺;催化;
In this review the stereoselective pharmacodynamics of calciumchannel blockers and chiral drugs are summarized. 本文就以手性药物和钙通道阻滞剂的药效学立体选择性作一综述。
Keywords Chiral phase transfer catalyst Alkylation; 手性相转移催化剂;烷基化;